cheesed off meaning: annoyed and disappointed with something or someone. Learn more. cheesed off (comparative more cheesed off, superlative most cheesed off). ( idiomatic, slang) Annoyed, upset, angry. I'm really cheesed off about the lack of hand. Oct 19, This Slang page is designed to explain what the meaning of cheesed off is. The slang word / phrase / acronym cheesed off means . Online.